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The reason for the lack of a positive inotropic effect (PIE) in RA can be readily understood if we assume that the negative staircase phenomenon is overcoming any PIE by an increase in cAMP in right atrial cardiomyocytes outside the sinus node (Stemmer and Akera 1986)

The Evaluate Renal Function With Semaglutide Once Weekly (FLOW) trial is the first dedicated kidney outcome study specifically designed to assess the effect of a GLP-1 receptor agonist (once-weekly subcutaneous semaglutide) in people with type 2 diabetes mellitus and CKD at high-risk of progression (Table 1, Fig

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